Hydrochloric Acid → HCID 21412103, compound

Participants

Reaction Steps

A solution of 1.0 g. (0.00317 mole) of 3-dimethylsulfamoyl-5H-dibenzo[a,d]cyclohepten-5-ol in a mixture of 2 ml. of dry dioxane and 2 ml. of absolute ether is cooled in ice and saturated with dry hydrogen chloride. The mixture is allowed to stand at room temperature for 5 hours and then is refrigerated overnight. The white crystalline product is collected, washed with petroleum ether, and dried in a vacuum desiccator over calcium chloride. The yield of 5-chloro-3-dimethylsulfamoyl-5H-dibenzo[a,d]cycloheptene is 600 mg., m.p. 139.5°-143.5° C. Dilution of the mother liquor with petroleum ether gives a second crop which is recrystallized from a mixture of ether and a petroleum ether affording 250 mg., m.p. 138.5°-142.5° C.

Provenance & Evidence