HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 1-methyl-4-phenyl-4-(N-benzylamino)-3-hydroxy piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 3-Methyl-6-phenyl-7-oxa-3-azabicyclo[4.1.0]heptane | HCID 435091 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 1-methyl-4-phenyl-4-(N-benzylamino)-3-hydroxy piperidine | HCID 21327187 | — |
Reaction Steps
A mixture comprising 3.7 g. of 1-methyl-4-phenyl-3,4-epoxypiperidine, 2.5 g. of benzylamine and 10 ml. of ethylene glycol was heated at 150° C. on an oil bath overnight. After work-up by the method described in Example 1, 5.45 g. of residue were obtained from which 4.11 g. of the desired free base 1-methyl-4-phenyl-4-(N-benzylamino)-3-hydroxy piperidine were isolated, this compound having a melting point of 162°-4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04048314 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-c8f4af270f7447eabefe7323c03f4200 |
| Source note | uspto-grants-1977_09 |