1,3-Dibromopropane → N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane

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Reaction Steps

15 g. of anhydrous potassium carbonate are added to a solution of 9 g. of 3-methylaminopropanol and 10 g. of 1,3-dibromopropane in 100 ml. of ethanol, and the reaction mixture is stirred and refluxed for 24 hours. The mixture is allowed to cool, filtered, the filtrate is evaporated, and the residue is distilled. 6 g. of N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane are obtained; b.p.: 150°-154° C/2 mmHg, nD20 = 1.4793.

Provenance & Evidence