HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | S-methyl isothiourea hemisulfate | HCID 6604939 | — |
| Reactant | 1-Methylhistamine dihydrochloride | HCID 11957601 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate | HCID 178481270 | — |
Reaction Steps
An aqueous of S-methylthiouronium sulphate (2.1 g) is added to a solution prepared from 1-methyl-4-(2-aminoethyl)imidazole dihydrochloride (3.0 g) and sodium hydroxide (1.21 g) in water. The resultant solution is heated under reflux for 17 hours. The product, isolated in a manner similar to that described in Example 1 is recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04048319 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-700f20f169d24d75a37f7e4d94f5be87 |
| Source note | uspto-grants-1977_09 |