HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroiodobenzene → 4-Acetyl-4'-fluoro-2-nitrobiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroiodobenzene | HCID 9605 | — |
| Reactant | 1-(4-Bromo-3-nitrophenyl)ethan-1-one | HCID 87737 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Acetyl-4'-fluoro-2-nitrobiphenyl | HCID 21320555 | — |
Reaction Steps
4-fluoroiodobenzene and 4-bromo-3-nitroacetophenone were reacted under Ullmann conditions to give 4-acetyl-4'-fluoro-2-nitrobiphenyl, m.p. 88°-90° C. (from methanol). This compound was reduced with stannous chloride in concentrated hydrochloric acid to give 4-acetyl-2-amino-4'-fluorobiphenyl, m.p. 88°-91° C. (from methanol). The amino group in this compound was converted to methoxy in the following way:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04048332 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-aed77874335a49f299104269746b499a |
| Source note | uspto-grants-1977_09 |