Acetic Acid → HCID 21320544, compound

Participants

Reaction Steps

A solution of 2-(4'-fluoro-2-methoxy-4-biphenylyl)-propionic acid (10 g.) in a mixture of hydrobromic acid (270 ml. of 48%w/v aqueous acid) and glacial acetic acid (90 ml.) was refluxed for 3.5 hours. The resulting solution was poured onto crushed ice, causing the precipitation of a solid product. This product was collected by filtration, washed with water, dried and recrystallised from chloroform/light petroleum (b.p. 62°-68° C.) to give 2-(4'-fluoro-2-hydroxy-4-biphenylyl)-propionic acid, m.p. 138°-142° C.

Provenance & Evidence