Ethylene Glycol → HCID 20333460, compound

Participants

Reaction Steps

2(2-Fluoro-4-biphenylyl)propionic acid (1 g.) ethylene glycol (10 ml.) and potassium hydroxide (0.8 g.) were refluxed under nitrogen for 24 hours. The mixture was diluted with water, washed with ether, acidified with hydrochloric acid and extracted with ether. The ether extract was washed with water, dried and evaporated to dryness. The product was subjected to thin layer chromatography to give 2-(2-hydroxy-4-biphenylyl)propionic acid, which was recrystallised from light petroleum (b.p. 80°-100° C.) to give the purified acid having a m.p. of 112°-119° C.

Provenance & Evidence