Diazomethane → HCID 21412655, compound

HRID 2071789Notes

Reaction equation

HRID 2071789 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[N+](=[CH2:21])=[N-]>>[OH:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([O:11][CH3:21])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 20333460HCID 20333460, compound

Product 1

HCID 21412655HCID 21412655, compound

Procedure

An ethereal solution of 2-(2-hydroxy-4-biphenylyl)propionic acid was treated with excess diazomethane and the resulting mixture evaporated to dryness under reduced pressure. The resulting product was triturated with light petroleum, b.p. 40°-60° C., collected by filtration and dried. The product was recrystallised twice from light petroleum (b.p. 80°-100° C.) to give methyl 2-(2-hydroxy-4-biphenylyl)propionate, m.p. 105.5°-107.5° C.

Workup

  1. customthe resulting mixture evaporated to dryness under reduced pressure
  2. customThe resulting product was triturated with light petroleum, b.p. 40°-60° C.
  3. filtrationcollected by filtration
  4. customdried
  5. customThe product was recrystallised twice from light petroleum (b.p. 80°-100° C.)

Sources & evidence

ORD record
ord-28fc3fa99ca147819698e4b3a2e67854
Source dataset
uspto-grants-1977_09
Patent number
US04048332

Reaction notes

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