Ethanol → HCID 21412650, compound

Participants

Reaction Steps

A solution of 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propionic acid (4.5 g.) in absolute ethanol (50 ml.) containing concentrated sulphuric acid (2 ml.) was refluxed overnight (16 hours). After distillation of ethanol the residue was poured onto ice-water and the product was isolated in ether. The extracts were washed with dilute sodium bicarbonate dried and evaporated. The solid residue thus obtained was purified by two crystallisations from light petrol (b.p. 62°-68° C.), to give ethyl 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propionate, m.p. 72°-73° C.

Provenance & Evidence