Water → HCID 21412653, compound

Participants

Reaction Steps

A solution of ethyl 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propionate (2.0 g.), from the previous Example, in dry ether (40 ml.) was added over 15 minutes in dry ether (40 ml.). After stirring under reflux for 1.5 hours, excess lithium aluminium hydride was decomposed by the cautious addition of water and finally with 2N sulphuric acid (10 ml.). The product was isolated in ether, washed, dried, evaporated and distilled to give a thick translucent oil, setting to a hard glass on cooling. Trituration with boiling light petroleum (b.p. 62°-68° C.) gave a crystalline solid. This was recrystallised from methylene chloride/light petroleum (b.p. 40°-60° C.) to give 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propan-1-ol, m.p. 118°-118.5° C.

Provenance & Evidence