Ammonia → HCID 21412652, compound

Participants

Reaction Steps

A solution of 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propionic acid (1.75 g.) and thionyl chloride (1 ml.) in dry benzene (10 ml.) was refluxed for 1 hour and then cooled and added dropwise to stirred cold ammonia (d=0.880 g./ml; 20 ml.). The product was filtered and recrystallised first from aqueous industrial methylated spirits and then light petroleum (b.p. 62°-68° C.) to give 2-(2',4'-difluoro-2-hydroxy-4-biphenylyl)propionamide, m.p. 222°-224° C.

Provenance & Evidence