1-Cyano-2,3-dimethylisothiourea → HCID 178485016, compound

HRID 2071927Notes

Reaction equation

HRID 2071927 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[S:10][CH:9]=[N:8][C:7]=1[CH3:11].[C:12]([NH:14][C:15](=[N:18][CH3:19])SC)#[N:13]>C(#N)C>[C:12]([NH:14][C:15]([NH:18][CH3:19])=[N:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[S:10][CH:9]=[N:8][C:7]=1[CH3:11])#[N:13]

Participants

4

Reactant 2

HCID 1111031-Cyano-2,3-dimethylisothioureaHCID 214100102-[[(4-Methyl-5-thiazolyl)methyl]thio]ethanamine

Product 1

HCID 178485016HCID 178485016, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 19.7 g. of 5-(2-aminoethyl)thiomethyl-4-methylthiazole and 11.2 g. of N-cyano-N', S-dimethylisothiourea in 500 ml. of acetonitrile is refluxed for 24 hours. The mixture is concentrated and the residue is chromatographed on a column of silica gel to give N-cyano-N'-methyl-N"-[2-(4-methyl-5-thiazolylmethylthio)ethyl]guanidine.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is chromatographed on a column of silica gel

Sources & evidence

ORD record
ord-9dc1c98db2f94c7eaf898e882d41bc22
Source dataset
uspto-grants-1977_09
Patent number
US04049669

Reaction notes

Loading…