Dimethylformamide → HCID 178484998, compound

Participants

Reaction Steps

A solution of N-cyano-N', S-dimethylisothiourea (0.81 g) and silver nitrate (1.06 g) in pyridine (100 ml) was added to a stirred mixture of 2-((5-methyl-4-imidazolyl)methylthio)-ethylamine (1.07 g), anhydrous potassium carbonate (0.44 g) and anhydrous dimethylformamide (4ml). The mixture was stirred at room temperature for 18 hours and filtered. The filtrate was evaporated to dryness and the residue was eluted from a column of silica gel using isopropyl alcoholethylacetate (1:4) followed by isopropyl alcohol-ethyl acetate (1:3) to give N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine (0.71 g) m.p. 139°-141° C.

Provenance & Evidence