Water → HCID 21409852, compound

Participants

Reaction Steps

1-(1-Formylaminomethylcyclohexyl)-4-methylpiperazine (5.97 g, 0.025 mole) was dissolved in dry benzene (100 ml) and added dropwise to a stirred suspension of lithium aluminum hydride (3.8 g; 0.1 mole) in dry ether (200 ml). The suspension was refluxed for four days and excess lithium aluminium hydride decomposed by the dropwise addition of water (8 ml), 30% sodium hydroxide solution (6 ml) and water (28 ml). The ether/benzene layer was separated, dried (Na2SO4) and evaporated to yield an amber, mobile oil (5.2 g. 93.0%) which failed to crystallise or produce stable salts. Distillation of this oil in vacuo gave 1-(1-methylaminomethylcyclohexyl)-4-methylpiperazine as a colourless oil.

Provenance & Evidence