反应详情

温度

90 °C

Conc. Sulphuric acid (8 ml.) was added to 2-dimethylamino-2-methyl-propionitrile (2 g.), and was heated to 90° C. and allowed to stand for five mins. The reaction mixture was added to ice cold water (100 ml.), barium hydroxide (32 g.) was added to neutralise the acid and the mixture was filtered (hyflo). The filtrate was evaporated under reduced pressure to give a solid residue which was crystallised from light petroleum (80°-100° C.) to give 2-dimethylamino-2-methylpropionamide (1 g. 45%) m.p. 109°-111° C.

1. additionwas added
2. filtrationthe mixture was filtered (hyflo)
3. customThe filtrate was evaporated under reduced pressure
4. customto give a solid residue which
5. customwas crystallised from light petroleum (80°-100° C.)