反应详情

A solution of 2-benzylmethylamino-2-methylpropionitrile (6.7 g.) in ether (100 ml.) was added dropwise to a stirred solution of sodium dihydro bis[2-methoxyethoxy] aluminate (28.5 g.) in ether (150 ml.), kept at 0° C. The mixture was then gently refluxed for 20 hrs, and then excess reducing agent was decomposed by the dropwise addition of water to the cooled suspension. The mixture was dried (anhyd.Na2SO4), filtered (hyflo) and the excess ether evaporated under reduced pressure. The residual liquid was distilled under water pump vacuum to give 2-benzylmethylamino-2-methyl-propylamine (3.8 g.) b.p. 138°-140° C.

1. customkept at 0° C
2. temperatureThe mixture was then gently refluxed for 20 hrs
3. dry with materialThe mixture was dried (anhyd.Na2SO4)
4. filtrationfiltered (hyflo)
5. customthe excess ether evaporated under reduced pressure
6. distillationThe residual liquid was distilled under water