Ethylenediamine → HCID 178484974, compound

HRID 2072115Notes

Reaction equation

HRID 2072115 reaction equation
C(N)CN.ClCC1SC=CN=1.[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[CH2:17][NH:18][CH2:19][CH2:20][NH2:21].[C:22]([NH:24][C:25](=[N:28][CH3:29])SC)#[N:23]>>[C:22]([NH:24][C:25]([NH:28][CH3:29])=[N:21][CH2:20][CH2:19][NH:18][CH2:17][C:13]1[S:12][CH:16]=[CH:15][N:14]=1)#[N:23]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 1111031-Cyano-2,3-dimethylisothioureaHCID 140908642-(Chloromethyl)-1,3-thiazoleHCID 17944882N-(2-thiazolylmethyl)ethylenediamine

Product 1

HCID 178484974HCID 178484974, compound

Procedure

Reacting ethylenediamine with 2-chloromethylthiazole by the procedure of Example 34, then reacting the resulting N-(2-thiazolylmethyl)ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(a), gives N-cyano-N'-methyl-N"-[2-(2thiazolylmethylamino)ethyl]guanidine. Hydrolysis of this compound by the procedure of Example 3(e) gives N-methyl-N'- [2-(2-thiazolylmethylamino)ethyl]guanidine trihydrochloride.

Sources & evidence

ORD record
ord-fa76e5cae38e417eae30b79283b6b16a
Source dataset
uspto-grants-1977_09
Patent number
US04049672

Reaction notes

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