HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyano-2,3-dimethylisothiourea → N-[2-(2-benzimidazolylmethylamino)ethyl]-N'-cyano-N"-methylguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyano-2,3-dimethylisothiourea | HCID 111103 | — |
| Reactant | N1-((1H-Benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine | HCID 15365342 | — |
| Product | N-[2-(2-benzimidazolylmethylamino)ethyl]-N'-cyano-N"-methylguanidine | HCID 54536364 | — |
Reaction Steps
Reacting N-(2-benzimidazolylmethyl)ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 36 gives N-[2-(2-benzimidazolylmethylamino)ethyl]-N'-cyano-N"-methylguanidine. Treating with hydrobromic acid gives the hydrobromide salt. Hydrolysis of this compound by the procedure of Example 3(e) gives N-[2-(2-benzimidazolylmethylamino)ethyl]-N'-methylguanidine trihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04049672 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-6ea25c25d06a4387b65230c99469dafc |
| Source note | uspto-grants-1977_09 |