Thiourea → HCID 68124224, compound

HRID 2072181Notes

Reaction equation

HRID 2072181 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9](Cl)[CH2:10][C:11](CC(Cl)C1C=CC(Cl)=CC=1Cl)=O.[NH2:25][C:26]([NH2:28])=[S:27]>C(O)C>[ClH:1].[NH2:25][CH:26]1[N:28]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[CH:10]=[CH:11][S:27]1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 86735082HCID 86735082, compound

Product 1

HCID 68124224HCID 68124224, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

24.0 g (0.1 mol) of 2.4-dichloro-phenyl-β-chloro-ethylketone (95%) are heated under reflux with 7.6 g (0.1 mol) of thiourea in 100 ml of ethanol. After approximately 3.5 hours, the reaction product has separated off as colourless crystals; 23.7 g (approximately 85% of the theory) of 2-amino-4-(2,4-dichloro-phenyl)-1,3-thiazine-hydrochloride are obtained as colourless crystals with a melting point of 236° C.

Workup

  1. customthe reaction product has separated off as colourless crystals

Sources & evidence

ORD record
ord-dfdc1e0dc1cb4aa2bcec8d994521d733
Source dataset
uspto-grants-1977_09
Patent number
US04049807

Reaction notes

Loading…