HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aminoethyl sulfate → 2-(2-Hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aminoethyl sulfate | HCID 70223 | — |
| Reactant | 2-(2-Phenylethyl)oxirane | HCID 135955 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-(2-Hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate | HCID 20354781 | — |
Reaction Steps
A mixture of 1,2-epoxy-4-phenylbutane (1.48g.) and 2-aminoethyl hydrogen sulphate (7.05 g.) in methanol (7.5 ml.) and sodium hydroxide solution (18N, 2.8 ml.) is stirred at ambient temperature for 2 hours. The 2-(2-hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate formed as intermediate is not isolated but is cyclised in situ as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04049808 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-e147bed855dc4fecaae78b256018f569 |
| Source note | uspto-grants-1977_09 |