Methanol → HCID 22802075, compound

Participants

Reaction Steps

3.0 g. of 6α,9α-difluoro-11β-hydroxy-16α-methyl-1,4-pregnadiene-3,20-dione is dissolved in 300 ml. of methanol. After adding 1.0 g. of copper (II) acetate, air is sucked through the solution for 30 minutes and the solution is then combined with saturated ammonium chloride solution. The mixture is extracted with dichloromethane, the organic phase is washed with water and dried over sodium sulfate. After evaporating the solvent under vacuum, 3.3 g. of 6α,9α-difluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-al is obtained in the form of a foam.

Provenance & Evidence