2-Chloroethanol → HCID 70634744, compound

Participants

Reaction Steps

3.3 g. of 6α,9α-difluoro-11βhydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-al is reacted under the conditions described in Example 46, but with 2-chloroethanol. The crude product is chromatographed on silica gel. With 25-27% acetone-hexane, after recrystallization from acetone/hexane, 1.11 g. of the 2-chloroethyl ester of 6α,9α-difluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-oic acid is obtained; m.p. 172.0° C. [α]D25 =+123° (chloroform). UV: ε238 = 17,200 (methanol).

Provenance & Evidence