HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → Fluocortin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | HCID 86735083 | HCID 86735083 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Fluocortin | HCID 22875828 | — |
Reaction Steps
1.0 g. of 6α-fluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-al is reacted, under the conditions described in Example 46 but with 2,2,2-trifluoroethanol, thus obtained the 2,2,2-trifluoroethyl ester of 6α-fluoro-11β-hydroxy-3,20-dioxo-16α-methyl-1,4-pregnadien-21-oic acid, m.p. 192.9° C. [α]D25 = +130° (chloroform). UV: ε242 = 17,000 (methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04049804 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-b9219958f5ad4ce1bb60ba2ae4d5f3bb |
| Source note | uspto-grants-1977_09 |