Sodium Hydroxide → HCID 13273294, compound

HRID 2072205Notes

Reaction equation

HRID 2072205 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH2:20][Cl:21])=[N:18][C:17]([C:22]([O:24]CC)=[O:23])=[N:16]1)=[O:8].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH2:20][Cl:21])=[N:18][C:17]([C:22]([OH:24])=[O:23])=[N:16]1)=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13273293HCID 13273293, compound

Product 1

HCID 13273294HCID 13273294, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3.0 g. of ethyl 1-[2-(2-pyridinecarbonyl)phenyl]-5-chloromethyl-1H-1,2,4-triazole-3-carboxylate in 40 ml. of ethanol is added 9 ml. of 1N-sodium hydroxide solution with stirring at room temperature. After strirring for 20 minutes, the solvent is evaporated by distillation, and neutralized with 9 ml. of 1N-hydrochloric acid. The precipitated crystals are collected by filtration, washed successively with water, ethanol and ether and then dried to give 1-[2-(2-pyridinecarbonyl)phenyl]-5-chloromethyl-1H-1,2,4-triazole-3-carboxylic acid as crystals. Recrystallization from ethanol gives colorless prisms, melting at 204° to 206° C. (decomposition).

Workup

  1. customthe solvent is evaporated by distillation
  2. filtrationThe precipitated crystals are collected by filtration
  3. washwashed successively with water, ethanol and ether
  4. customdried

Sources & evidence

ORD record
ord-53163f9156724d928ddf4dec78fb18d0
Source dataset
uspto-grants-1977_09
Patent number
US04049812

Reaction notes

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