2-Methylimidazole → HCID 13273295, compound

HRID 2072207Notes

Reaction equation

HRID 2072207 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]=[N:16][CH:17]([NH:21][C:22](=O)[CH2:23][Cl:24])[C:18]([NH2:20])=[O:19])=[O:8].CC1NC=CN=1>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:22]([CH2:23][Cl:24])=[N:21][C:17]([C:18]([NH2:20])=[O:19])=[N:16]1)=[O:8]

Participants

4

Reactant 2

HCID 127492-MethylimidazoleHCID 21410921HCID 21410921, compound

Product 1

HCID 13273295HCID 13273295, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.3 g. of [2-(2-pyridinecarbonyl)-phenyl]azo-(2-chloroacetamido)acetamide and 0.82 g. of 2-methylimidazole in 12ml. of ethanol is refluxed for one hour and then cooled. The precipitated crystals are collected by filtration to give 1-[2-(2-pyridinecarbonyl)phenyl]-5-chloromethyl-1H-1,2,4-triazole-3-carboxamide as crystals. Recrystallization from chloroform-ethanol gives colorless needles, melting at 228° to 229° C. (decomposition).

Workup

  1. temperaturecooled
  2. filtrationThe precipitated crystals are collected by filtration

Sources & evidence

ORD record
ord-d118a85bf13f42e3b3090d38c552d806
Source dataset
uspto-grants-1977_09
Patent number
US04049812

Reaction notes

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