Sodium Hydroxide → HCID 13273301, compound

HRID 2072208Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][Cl:14])=[N:11][C:10]([C:15]([O:17]CC)=[O:16])=[N:9]2)=[C:4]([C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)=[O:21])[CH:3]=1.[OH-].[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][Cl:14])=[N:11][C:10]([C:15]([OH:17])=[O:16])=[N:9]2)=[C:4]([C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)=[O:21])[CH:3]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 13273296HCID 13273296, compound

Product 1

HCID 13273301HCID 13273301, compound

Procedure

According to the same manner as in Preparative Example 5, ethyl 1-[4-bromo-2-(2-pyridinecarbonyl)phenyl]-5-chloromethyl-1H-1,2,4-triazole-3-carboxylate is hydrolyzed with sodium hydroxide to give 1-[4-bromo-2-(2-pyridinecarbonyl)-phenyl]-5-chloromethyl-1H-1,2,4-triazole-3-carboxylic acid as crystals. Recrystallizations from ethanol gives colorless prisms, melting at 215° C to 217° C. (decomposition).

Sources & evidence

ORD record: ord-0dd8f2699af047a6a551d0b5454276bc
Source dataset: uspto-grants-1977_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04049812

Reaction notes

Loading…