Potassium Hydroxide → 3p-Phenoxyphenyl-3-hydroxybutyric acid

HRID 2072230Notes

Reaction equation

HRID 2072230 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:20])([CH3:19])[CH2:15][C:16](N)=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:21].[K+]>C(O)C>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:20])([CH3:19])[CH2:15][C:16]([OH:21])=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 54572878HCID 54572878, compound

Product 1

HCID 541805473p-Phenoxyphenyl-3-hydroxybutyric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

g. of 3-p-phenoxyphenyl-3-hydroxybutyric acid amide (obtainable from 4-phenoxyacetophenone and bromoacetamide/zinc) and 5 g. of KOH in 100 ml. of ethanol are boiled for 3 hours under nitrogen. The mixture is evaporated and worked up to give 3-p-phenoxyphenyl-3-hydroxybutyric acid, m.p. 137°-138°.

Workup

  1. customThe mixture is evaporated

Sources & evidence

ORD record
ord-46f33f0b316e41d98ea169674f442ba1
Source dataset
uspto-grants-1977_09
Patent number
US04049823

Reaction notes

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