Water → HCID 178506287, compound

HRID 2072293Notes

Reaction equation

HRID 2072293 reaction equation
[F:1][C:2]([F:13])([F:12])[CH2:3][C:4]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:5]=1[NH2:6].[N:14]([O-])=O.[Na+].O>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[C:4]2[C:5](=[CH:7][CH:8]=[C:9]([Br:11])[CH:10]=2)[NH:6][N:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 213977532-(2,2,2-Trifluoro-ethyl)-4-bromo-anilineHCID 23668193Sodium Nitrite

Product 1

HCID 178506287HCID 178506287, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
15 °C

Procedure

18 parts of 2-(2,2,2-trifluoro-ethyl)-4-bromo-aniline are dissolved in 490 parts by volume of glacial acetic acid. To this solution, well stirred at 15° C., is added all at once a solution of 4.9 parts of sodium nitrite in 11.9 parts of water. At the end of 3 days, the acetic acid is evaporated and the residue is taken up in 40 parts of water, the solid filtered off, washed and dried. 18 parts of 3-trifluoromethyl-5-bromo-indazole are thus obtained.

Workup

  1. customAt the end of 3 days, the acetic acid is evaporated
  2. filtrationthe solid filtered off
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-25b7c147f43c4cf8aad3cb4d6b186cb8
Source dataset
uspto-grants-1977_09
Patent number
US04051145

Reaction notes

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