HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4H-Pyran-3-carboxylic acid, 2,6-dimethyl-4-oxo-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,6-Dimethyl-4-oxo-4H-pyran-3-carboxylic acid | HCID 201105 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4H-Pyran-3-carboxylic acid, 2,6-dimethyl-4-oxo-, methyl ester | HCID 12281371 | — |
Reaction Steps
42 g of 3-carboxy-2,6-dimethylpyr-4-one is dissolved in 250 ml of methylene chloride. In a second flask, 20 ml of acetyl chloride is cautiously added to 400 ml of methanol. The two solutions are mixed and refluxed for five hours. Solid sodium carbonate is added and the solvent removed after a water wash. The residue is distilled (115°-125° at 0.1 mm) to give 40 g of 3-carbomethoxy-2,6-dimethylpyr-4-one as a waxy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051142 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-5d18beedd07a42abb6f9921a2a369e22 |
| Source note | uspto-grants-1977_09 |