HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Acetoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2-Hydroxy-3,3-dimethyl-2H-1-benzofuran-5-yl) methanesulfonate | HCID 536079 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Acetoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate | HCID 13088532 | — |
Reaction Steps
To a solution of 2-hydroxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate (10 parts) in water (100 parts) containing sodium hydroxide (15 parts) was slowly added acetic anhydride (10 parts) with cooling to keep the temperature below 10° C. An oil separated which solidified on scratching. This was filtered off, washed with water, dried and recrystallised from 90% aqueous ethanol to give 2-acetoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate, melting point 84°-85° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051154 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-b4742912cf254406b903b821c1c42c98 |
| Source note | uspto-grants-1977_09 |