Sodium Hydroxide → HCID 21407939, compound

HRID 2072360Notes

Reaction equation

HRID 2072360 reaction equation
[O:1]([CH:8]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:17][CH:16]=1)[C:9]([O:11]CC)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[O:1]([CH:8]([O:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:19][CH:20]=1)[C:9]([OH:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54408684HCID 54408684, compound

Product 1

HCID 21407939HCID 21407939, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.55 g. of ethyl phenoxy-(4-piperidinophenoxy)-acetate is refluxed with 1 g. of NaOH in 40 ml. of methanol for 4 hours. The mixture is concentrated by evaporation, mixed with water, washed with ether, hydrochloric acid is added thereto to a pH of 5, and phenoxy-(4-piperidinophenoxy)-acetic acid is thus obtained.

Workup

  1. concentrationThe mixture is concentrated by evaporation
  2. additionmixed with water
  3. washwashed with ether, hydrochloric acid
  4. additionis added

Sources & evidence

ORD record
ord-878beb7e4c814287bf3f09d2ba6f9359
Source dataset
uspto-grants-1977_09
Patent number
US04051170

Reaction notes

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