1,5-Dibromopentane → HCID 21407936, compound

Participants

Reaction Steps

2.3 g. of 1,5-dibromopentane, 3.2 g. of (4-chlorophenoxy)-(4-aminophenoxy)-acetic acid ethyl ester [obtainable by reacting Na-4-nitrophenolate with α-bromo-α-(4-chlorophenoxy)-acetic acid ethyl ester to obain the ethyl ester of (4-chlorophenoxy)-(4-nitrophenoxy)-acetic acid and subsequent hydrogenation], and 1.4 g. of K2CO3 are refluxed for 12 hours in 40 ml. of n-butanol. As an intermediate compound, the ethyl ester of (4-chlorophenoxy)-[4-(5-bromopentylamino)-phenoxy]-acetic acid is produced. After working up the mixture as usual, (4-chlorohenoxy)-(4-piperidinophenoxy)-acetic acid ethyl ester is obtained.

Provenance & Evidence