1-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea → (1,2,3,4-Tetrahydronaphthalen-1-yl)urea

HRID 2072369Notes

Reaction equation

HRID 2072369 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1>[OH-].[Na+]>[CH:13]1([NH:12][C:10]([NH2:9])=[O:11])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 1

HCID 205373051-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea

Product 1

HCID 13037020(1,2,3,4-Tetrahydronaphthalen-1-yl)ureaYield 89%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 1-benzoyl-3-(1,2,3,4-tetrahydro-1- naphthyl)urea (2.0 g) and aqueous sodium hydroxide (1N; 20 ml) is stirred and heated at reflux for 2.75 hours. The mixture is then cooled in ice and the product is collected and washed with water to afford 1.15 g of the title compound, m.p. 204° to 207° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 2.75 hours
  3. temperatureThe mixture is then cooled in ice
  4. customthe product is collected
  5. washwashed with water

Sources & evidence

ORD record
ord-a4872d8c1d9e44cdbccfd65c56a19459
Source dataset
uspto-grants-1977_09
Patent number
US04051183

Reaction notes

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