Alprostadil → HCID 20277168, compound

HRID 2072380Notes

Reaction equation

ClC1[CH:24]=[CH:23][C:5]2N(C)[C:7](=[O:21])[C:8]3[CH:15]=[N:14][C:13]4[N:16]([CH2:19][CH3:20])[N:17]=[CH:18][C:12]=4[C:9]=3[N:10](C)[C:4]=2C=1.CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](CCCCCC[C:45]([OH:47])=[O:46])C(=O)C[C@H]1O>>[CH2:4]([NH:10][C:9]1[C:8]2[C:7](=[O:21])[O:46][CH:45]([OH:47])[C:15]=2[N:14]=[C:13]2[N:16]([CH2:19][CH3:20])[N:17]=[CH:18][C:12]=12)[CH2:5][CH2:23][CH3:24]

Participants

Reactant 2

HCID 5280723Alprostadil

HCID 20471312HCID 20471312, compound

Product 1

HCID 20277168HCID 20277168, compound

Procedure

10-Chloro-3-ethyl-7,12-dimethyl-7,12-dihydropyrazolo-[4',3':5,6]pyrido[4,3-b][1,5]benzodiazepin-6(3H)-one, said PGE1 being present in a concentration of from about 10-6 molar to about 10-9 molar, and said compound being present in a concentration of from about 0.1 mM to about 4 mM.

Sources & evidence

ORD record: ord-ae8ece632a3e4e3d8de50b5604f536f4
Source dataset: uspto-grants-1977_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04051236

Reaction notes

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