HCID 178430952, compound → Demannose

Participants

Reaction Steps

The sugar component of Bu-2231 A and B was. also investigated comparatively with bleomycin. A mixture of components A and B was refluxed in methanol with a strongly acidic resin (Amberlyst 15) for 20 hours. Basic fragments from the hydrolysis were adsorbed on the resin and neutral products liberated in the solution were concentrated in vacuo to a sticky syrup. This material was trimethylsilyated and then subjected to gas-chromatographic analysis. Bleomycin gave peaks assignable to gulose and mannose, and the Bu-2231 components showed nearly the same elution pattern as that of bleomycin, indicating the same structure of the carbohydrate portion in the antibiotics.

Provenance & Evidence