反应详情

A solution of diazomethane in methylene chloride was added to a suspension of 10.45g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.

1. distillationthe methylene chloride was distilled The oily residue
2. customwas chromatographed over silica
3. washwas eluted with a 1:1 mixture of benzene-ethyl acetate