Diazomethane → HCID 21408257, compound

HRID 2072387Notes

Reaction equation

HRID 2072387 reaction equation
[N+](=[CH2:3])=[N-].[CH2:4]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)[CH3:5]>C(Cl)Cl>[CH2:4]([C:6]1[S:7][C:8]([C:11]([O:13][CH3:3])=[O:12])=[CH:9][N:10]=1)[CH3:5]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 2077555-Thiazolecarboxylic acid, 2-ethyl-

Product 1

HCID 21408257HCID 21408257, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of diazomethane in methylene chloride was added to a suspension of 10.45g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.

Workup

  1. distillationthe methylene chloride was distilled The oily residue
  2. customwas chromatographed over silica
  3. washwas eluted with a 1:1 mixture of benzene-ethyl acetate

Sources & evidence

ORD record
ord-994636cd792e4588bfe93b07f6dd5b5c
Source dataset
uspto-grants-1977_09
Patent number
US04051249

Reaction notes

Loading…