HCID 68123068, compound → Bay-H-1127

HRID 2072405Notes

Reaction equation

HRID 2072405 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=2)[NH:4][N:3]=1.COC(N1C=C2C(C=CC=C2)=N1)=O>COC(OC(OC)=O)=O>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:13])([F:12])[F:14])[CH:9]=2)[NH:4][N:3]=1

Participants

3

Reactant 1

HCID 68123068HCID 68123068, compound

Product 1

HCID 16736Bay-H-1127

Reagents, catalysts & solvents 1

HCID 3086Dimethyl dicarbonateSolvent

Procedure

Analogously to Example 1, 0.1 mol of 3-amino-5trifluoromethyl-indazole in 50 ml of pyrocarbonic acid dimethyl ester gives 3-amino-5-trifluoromethylindazole-indazole-2-carboxylic acid methyl ester (melting point: 164°-165° C; 64% of theory) in 2 hours at 50° C.

Sources & evidence

ORD record
ord-ebc40440b14e4f86be192903986df4dc
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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