HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Pyrocarbonate → 3-Amino-6-(trifluoromethyl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Pyrocarbonate | HCID 3051 | — |
| Reactant | 3-Amino-6-trifluoromethylindazole-1-carboxylic acid ethyl ester | HCID 53694665 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-6-(trifluoromethyl)-1H-indazole | HCID 817909 | — |
Reaction Steps
Analogously to Example 22, 0.04 mol of 3-amino-6-trifluoromethylindazole and 50 ml of pyrocarbonic acid diethyl ester in 25 ml of ethanol give 3-amino-6-trifluoromethylindazole-1-carboxylic acid ethyl ester (melting point: 168°-169° C; 64% of theory) in 2 hours at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051252 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-45663ffc510940dfb989d3afcbed9a56 |
| Source note | uspto-grants-1977_09 |