3-Amino-6-chloroindazole-1-carboxylic acid methylamide → Methyl Isocyanate

HRID 2072415Notes

Reaction equation

HRID 2072415 reaction equation
[CH3:1][NH:2][C:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[C:7]([NH2:15])=[N:6]1)=[O:4]>N1C=CC=CC=1>[NH2:15][C:7]1[C:8]2[C:13](=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[NH:5][N:6]=1.[CH3:1][N:2]=[C:3]=[O:4]

Participants

4

Reactant 1

HCID 537794063-Amino-6-chloroindazole-1-carboxylic acid methylamide

Product 2

HCID 12228Methyl IsocyanateHCID 856286-chloro-1H-indazol-3-amine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Analogously to Example 46, 0.1 mol of 3-amino-6-chloroindazole and 0.1 mol of methyl isocyanate in 100 ml of pyridine give 3-amino-6-chloroindazole-1-carboxylic acid methylamide (melting point: 148°-150° C; 50% of theory) in 30 minutes at 10°-15° C.

Sources & evidence

ORD record
ord-c8618990cb2b4201924ca28097203f57
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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