Formaldehyde → HCID 53728058, compound

HRID 2072417Notes

Reaction equation

HRID 2072417 reaction equation
C=O.[CH2:3]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[C:10]([N:18](C)C)=[N:9]1)=[O:7])[CH3:4]>C(O)=O>[CH2:3]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[C:10]([NH2:18])=[N:9]1)=[O:7])[CH3:4]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 54073960HCID 54073960, compound

Product 1

HCID 53728058HCID 53728058, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Analogously to Example 49, 0.1 mol of 3-amino-6-chloroindazole-1-carboxylic acid ethyl ester and 0.25 mol of 40% strength formaldehyde solution in 150 ml of formic acid give 3-dimethylamino-6-chloroindazole-1-carboxylic acid ethyl ester (melting point: 98°-100° C; 69% of theory) in 5 hours at 100° C.

Sources & evidence

ORD record
ord-8fdef5d658624d14b050847721906977
Source dataset
uspto-grants-1977_09
Patent number
US04051252

Reaction notes

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