HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Acetamide, 2-chloro-2,2-difluoro-N-(2-methyl-4-(((methylamino)carbonyl)oxy)phenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Aminomatacil | HCID 25072 | — |
| Reactant | Chlorodifluoroacetyl chloride | HCID 67713 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Acetamide, 2-chloro-2,2-difluoro-N-(2-methyl-4-(((methylamino)carbonyl)oxy)phenyl)- | HCID 3049451 | — |
Reaction Steps
According to general procedures outlined above, 3-methyl-4-aminophenyl N-methylcarbamate (2.3g., 0.0128 mole) was reacted with chlorodifluoroacetyl chloride (2.1g., 0.014 mole) in the presence of triethylamine (1.4g., 0.014 mole) and benzene. The product was a light tan solid (1.6g., m.p. 156°-58.5° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051254 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-0d46871eb8834712b48386bc176420fe |
| Source note | uspto-grants-1977_09 |