Ethanesulfonyl chloride → Ethanesulfonamide, N-[2,6-dimethyl-4-[[(methylamino)carbonyl]oxy]phenyl]-

Participants

Reaction Conditions

Reaction Steps

3,5-Dimethyl-4-aminophenyl N-methylcarbamate (1.0g., 0.0052 mole), prepared according to the general directions of A. T. Shulgin, U.S. Pat. No. 3,084,098 was dissolved in 5 ml. of pyridine. To this solution was added ethanesulfonyl chloride (0.68g., and 0.0053 mole) and after being stirred for about 20 minutes the reaction solution was warmed briefly at 42° C. Quenching the reaction solution in excess water yielded brown solids which upon being recrystallized from ethanol/water melted at 171°-73° C. (0.85g.).

Provenance & Evidence