Ammonia → HCID 178512021, compound

HRID 2072441Notes

Reaction equation

HRID 2072441 reaction equation
[CH:1]1([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=S)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:18]>C(O)C>[CH:1]1([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[NH:18])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 709206N-(4-chlorophenyl)-N'-cyclohexylthiourea

Product 1

HCID 178512021HCID 178512021, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Cyclohexyl-3-(p-chlorophenyl)thiourea (2.0 g.) was dissolved in absolute ethyl alcohol saturated with ammonia (40 ml.). To this was added yellow mercuric oxide (1.7 g.) and the mixture stirred at room temperature for 16 hours. The mixture was then refluxed 15 minutes to coagulate the fine precipitate of mercuric sulphide, filtered and the clear filtrate evaporated to dryness. The residue was recrystallised from toluene to give 1-cyclohexyl-3-(p-chlorophenyl)guanidine, m.p. 187°-190°.

Workup

  1. temperatureThe mixture was then refluxed 15 minutes
  2. filtrationfiltered
  3. customthe clear filtrate evaporated to dryness
  4. customThe residue was recrystallised from toluene

Sources & evidence

ORD record
ord-98650856c0fb4485859013700ef65377
Source dataset
uspto-grants-1977_09
Patent number
US04051256

Reaction notes

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