Ammonia → HCID 178512019, compound

HRID 2072443Notes

Reaction equation

HRID 2072443 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=S)[NH:10][CH:11]2[CH:16]3[CH2:17][CH:13]4[CH:14]([CH2:15]3)[CH:12]24)=[CH:4][CH:3]=1.[NH3:19]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[NH:19])[NH:10][CH:11]2[CH:16]3[CH2:17][CH:13]4[CH:14]([CH2:15]3)[CH:12]24)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 53659140HCID 53659140, compound

Product 1

HCID 178512019HCID 178512019, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-[3-(p-chlorophenyl)thioureido]tricyclo[2,2,1,02,6 ]heptane (0.25 g.) in ethanol saturated with ammonia (10 ml.) was added 0.2 g. of yellow mercuric oxide, and the mixture stirred at room temperature for 16 hours. The solids were filtered off and the clear filtrate evaporated to dryness. The residual solid was recrystallised from toluene to give 3-[3-(p-chlorphenyl)guanidino]tricyclo[2,2,1,02,6 ]heptane, m.p. 204°-205°.

Workup

  1. filtrationThe solids were filtered off
  2. customthe clear filtrate evaporated to dryness
  3. customThe residual solid was recrystallised from toluene

Sources & evidence

ORD record
ord-844f779e88884754a90bd6b98889f9e0
Source dataset
uspto-grants-1977_09
Patent number
US04051256

Reaction notes

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