1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21408213, compound

HRID 2072466Notes

Reaction equation

HRID 2072466 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][C:10]([O:17][CH3:18])=[C:11]([O:15][CH3:16])[CH:12]=2)[C:7]1=[O:19])[CH3:4].[C:20]1([N:26]2[C:30]3([CH2:35]CNC[CH2:31]3)[C:29](=[O:36])[NH:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[CH3:16][O:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][C:10]=1[O:17][CH3:18])[C:7](=[O:19])[CH:6]([CH2:5][N:3]1[CH2:4][CH2:35][C:30]3([N:26]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:27][NH:28][C:29]3=[O:36])[CH2:31][CH2:2]1)[CH2:14]2

Participants

4

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 118714896HCID 118714896, compound

Product 1

HCID 21408213HCID 21408213, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[(Dimethylamino)methyl]-5,6-dimethoxy-1-indanone, hydrochloride (1:1) (2.0 g) and 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (1.94 g) are stirred for 20 hours in 20 ml of absolute ethanol while a slow stream of nitrogen is bubbled through. The resultant precipitate is filtered off and dried to yield 2.75 g of the title compound, melting point 174°-177° C.

Workup

  1. customis bubbled through
  2. filtrationThe resultant precipitate is filtered off
  3. customdried

Sources & evidence

ORD record
ord-88b01d7a96144a15a874e36fc0def4d5
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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