Hydrochloric Acid → HCID 131710906, compound

Participants

Reaction Steps

8-[(2,3-Dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (2.75 g) is taken up in 400 ml of boiling dioxane and filtered while hot. The filtrate is concentrated to half its original volume, cooled and treated with 1.2 equivalents of a solution of hydrogen chloride in dioxane. The resulting solution is then diluted with 200 ml of ether and chilled. The crude hydrochloride salt thus obtained is triturated with boiling absolute ethanol (50 ml), cooled and filtered to yield 1.68 g of the title compound, melting point 210°-211° C.

Provenance & Evidence