HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Anilinopiperidine-4-carboxamide | HCID 96428 | — |
| Reactant | 3-(Chloromethyl)-1,2-dihydronaphthalene | HCID 12771433 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide | HCID 21408223 | — |
Reaction Steps
A mixture of 4-anilino isonipecotamide (5.5 g), 3,4-dihydro-2-chloromethylnaphthalene (4.0 g), and powdered sodium carbonate (3.5 g) in toluene (200 ml) containing several crystals of iodine is refluxed for 14 hours with vigorous stirring under nitrogen. The reaction mixture is then cooled, diluted with methylene chloride (100 ml), and filtered. The filtrate is concentrated and the crude product triturated with ethyl acetate (100 ml) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051248 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-489e56ecdefa4457972d39fdb2be6887 |
| Source note | uspto-grants-1977_09 |