HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2072473Generated: October 30, 2026
Sulfuric Acid → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide
https://huagongshe.com/reaction/2072473
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile | HCID 53707030 | — |
| Product | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide | HCID 21408223 | — |
Reaction Steps
A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile (5.0 g) and 90% sulfuric acid (60.0 g) is heated for 10 minutes at 70° C. The mixture is then stirred at room temperature for an additional hour. The reaction mixture is poured into ice-water, basified with ammonium hydroxide, and extracted with chloroform. Concentration of the dried chloroform solution followed by trituration with benzene yields the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04051248 |
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| Source dataset | uspto-grants-1977_09 |
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| ORD ID | ord-5252351b68534317b9ddf53e3f6ec849 |
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| Source note | uspto-grants-1977_09 |
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