HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-oxopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Piperidone | HCID 33721 | — |
| Reactant | 3-(Chloromethyl)-1,2-dihydronaphthalene | HCID 12771433 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-oxopiperidine | HCID 21408225 | — |
Reaction Steps
A mixture of 4-piperidone (2.2 g), 3,4-dihydro-2-chloromethylnaphthalene (4.0 g), and powdered sodium carbonate (3.5 g) in tolune (200 ml) containing several crystals of iodine is refluxed for 14 hours with vigorous stirring under nitrogen. The reaction mixture is then cooled, diluted with methylene chloride (100 ml), and filtered. The filtrate is concentrated and the crude product triturated with 1:1 hexane/ether (100 ml) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04051248 |
| Source dataset | uspto-grants-1977_09 |
| ORD ID | ord-368f8c5c12274854af6fdcce13cb5c20 |
| Source note | uspto-grants-1977_09 |