HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2072477Generated: October 31, 2026
Aniline → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile
https://huagongshe.com/reaction/2072477
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-oxopiperidine | HCID 21408225 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile | HCID 53707030 | — |
Reaction Steps
A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-oxopiperidine (24.0 g), aniline (9.3 g), and glacial acetic acid (70 ml) is cooled to 30° C and heated with a solution of potassium cyanide (7.2 g) in water (20 ml). The resulting mixture is stirred for 16 hours at room temperature. The reaction mixture is poured into aqueous ammonium hydroxide and extracted with chloroform. The organic solution is dried and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04051248 |
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| Source dataset | uspto-grants-1977_09 |
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| ORD ID | ord-f55c85131ed143b1bd9418451088a7dd |
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| Source note | uspto-grants-1977_09 |
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